PASI 90 PASI 90
PASI 100 PASI 100

In an open-label extension

PATIENTS SWITCHED FROM STELARA® (ustekinumab)* TO SKYRIZI ACHIEVED HIGHER PASI 90 RATES AT 2.5 YEARS3,4

KEY VARIABLES MEASURED EVERY 12 WEEKS THROUGH OLE5,8:

sPGA 0/1, sPGA 0, PASI 75, PASI 90, and PASI 100

Following completion of the RCT period, patients on blinded STELARA were switched to open-label SKYRIZI.4

LIMITATIONS:

In an open-label extension, there is potential for enrichment of the long-term data in the remaining patient populations since patients who are unable to tolerate or do not respond to the drug often drop out.

*ACTIVE COMPARATOR

The ustekinumab used as a biologic active control in UltIMMa-1 and UltIMMa-2 was sourced from the European Union. Comparability between non–US-approved ustekinumab and US-approved ustekinumab has not been established.

STELARA is a registered trademark of Johnson & Johnson. See US Prescribing Information for further information.

73% OF PATIENTS ACHIEVED PASI 90 AFTER 1 DOSE (12 WEEKS) OF SKYRIZI3,4

INTEGRATED RESULTS FROM ULTIMMA-1 & -2 PATIENTS (LOCF)

Chart depicting 73% of patients achieved PASI 90 after 1 dose at Week 12 of SKYRIZI®. Chart depicting 73% of patients achieved PASI 90 after 1 dose at Week 12 of SKYRIZI®. Chart depicting 73% of patients achieved PASI 90 after 1 dose at Week 12 of SKYRIZI®.

KEY VARIABLES MEASURED EVERY 12 WEEKS THROUGH OLE5,8:

sPGA 0/1, sPGA 0, PASI 75, PASI 90, and PASI 100

Following completion of the RCT period, patients on blinded STELARA were switched to open-label SKYRIZI.4

LIMITATIONS:

In an open-label extension, there is potential for enrichment of the long-term data in the remaining patient populations since patients who are unable to tolerate or do not respond to the drug often drop out.

*ACTIVE COMPARATOR

The ustekinumab used as a biologic active control in UltIMMa-1 and UltIMMa-2 was sourced from the European Union. Comparability between non–US-approved ustekinumab and US-approved ustekinumab has not been established.

STELARA is a registered trademark of Johnson & Johnson. See US Prescribing Information for further information.

STUDY DESIGN:

The randomized controlled trial data shown here are integrated results from UltIMMa-1 and -2. The open-label extension (OLE) data are a sub-analysis of LIMMitless and include only patients from UltIMMa-1 and -2 who completed the RCT and then enrolled in the OLE. LIMMitless is an OLE for which patients who completed either UltIMMa trial, IMMhance, or IMMvent were eligible to participate.4-7

VIEW STUDY DESIGN AND BASELINE CHARACTERISTICS

LOCF=Last observation carried forward; OLE=Open-label extension; RCT=Randomized controlled trial.

In the randomized controlled trial and open-label extension

PATIENTS WHO STARTED AND REMAINED ON SKYRIZI EXPERIENCED CONSISTENT PASI 90 RATES AT 2.5 YEARS3,4

KEY VARIABLES MEASURED EVERY 12 WEEKS THROUGH OLE5,8:

sPGA 0/1, sPGA 0, PASI 75, PASI 90, and PASI 100

Following completion of the RCT period, patients on blinded STELARA were switched to open-label SKYRIZI.4

LIMITATIONS:

In an open-label extension, there is potential for enrichment of the long-term data in the remaining patient populations since patients who are unable to tolerate or do not respond to the drug often drop out.

*ACTIVE COMPARATOR

The ustekinumab used as a biologic active control in UltIMMa-1 and UltIMMa-2 was sourced from the European Union. Comparability between non–US-approved ustekinumab and US-approved ustekinumab has not been established.

STELARA is a registered trademark of Johnson & Johnson. See US Prescribing Information for further information.

86% OF SKYRIZI PATIENTS ACHIEVED PASI 90 AT WEEK 52 AND 87% AT WEEK 1363,4

INTEGRATED RESULTS FROM ULTIMMA-1 & -2 PATIENTS (LOCF)

Chart depicting 86% of patients achieved PASI 90 at Week 52 and 87% at week 136 who started and remained on SKYRIZI®. Chart depicting 86% of patients achieved PASI 90 at Week 52 and 87% at week 136 who started and remained on SKYRIZI®. Chart depicting 86% of patients achieved PASI 90 at Week 52 and 87% at week 136 who started and remained on SKYRIZI®.

KEY VARIABLES MEASURED EVERY 12 WEEKS THROUGH OLE5,8:

sPGA 0/1, sPGA 0, PASI 75, PASI 90, and PASI 100

Following completion of the RCT period, patients on blinded STELARA were switched to open-label SKYRIZI.4

LIMITATIONS:

In an open-label extension, there is potential for enrichment of the long-term data in the remaining patient populations since patients who are unable to tolerate or do not respond to the drug often drop out.

*ACTIVE COMPARATOR

The ustekinumab used as a biologic active control in UltIMMa-1 and UltIMMa-2 was sourced from the European Union. Comparability between non–US-approved ustekinumab and US-approved ustekinumab has not been established.

STELARA is a registered trademark of Johnson & Johnson. See US Prescribing Information for further information.

STUDY DESIGN:

The randomized controlled trial data shown here are integrated results from UltIMMa-1 and -2. The open-label extension (OLE) data are a sub-analysis of LIMMitless and include only patients from UltIMMa-1 and -2 who completed the RCT and then enrolled in the OLE. LIMMitless is an OLE for which patients who completed either UltIMMa trial, IMMhance, or IMMvent were eligible to participate.4-7

VIEW STUDY DESIGN AND BASELINE CHARACTERISTICS

LOCF=Last observation carried forward; OLE=Open-label extension; RCT=Randomized controlled trial.

VIEW PASI 100 DATA

In an open-label extension

PATIENTS SWITCHED FROM STELARA® (ustekinumab)* TO SKYRIZI ACHIEVED HIGHER PASI 100 RATES AT 2.5 YEARS3,4

KEY VARIABLES MEASURED EVERY 12 WEEKS THROUGH OLE5,8:

sPGA 0/1, sPGA 0, PASI 75, PASI 90, and PASI 100

Following completion of the RCT period, patients on blinded STELARA were switched to open-label SKYRIZI.

LIMITATIONS:

In an open-label extension, there is potential for enrichment of the long-term data in the remaining patient populations since patients who are unable to tolerate or do not respond to the drug often drop out.

*ACTIVE COMPARATOR

The ustekinumab used as a biologic active control in UltIMMa-1 and UltIMMa-2 was sourced from the European Union. Comparability between non–US-approved ustekinumab and US-approved ustekinumab has not been established.

STELARA is a registered trademark of Johnson & Johnson. See US Prescribing Information for further information.

51% OF SKYRIZI PATIENTS ACHIEVED COMPLETE CLEARANCE (PASI 100) AFTER 1 DOSE (12 WEEKS) OF SKYRIZI3,4

INTEGRATED RESULTS FROM ULTIMMA-1 & -2 PATIENTS (LOCF)

Chart depicting 51% of patients achieved complete clearance (PASI 100) after 1 Dose (12 weeks) of SKYRIZI®. Chart depicting 51% of patients achieved complete clearance (PASI 100) after 1 Dose (12 weeks) of SKYRIZI®. Chart depicting 51% of patients achieved complete clearance (PASI 100) after 1 Dose (12 weeks) of SKYRIZI®.

KEY VARIABLES MEASURED EVERY 12 WEEKS THROUGH OLE5,8:

sPGA 0/1, sPGA 0, PASI 75, PASI 90, and PASI 100

Following completion of the RCT period, patients on blinded STELARA were switched to open-label SKYRIZI.

LIMITATIONS:

In an open-label extension, there is potential for enrichment of the long-term data in the remaining patient populations since patients who are unable to tolerate or do not respond to the drug often drop out.

*ACTIVE COMPARATOR

The ustekinumab used as a biologic active control in UltIMMa-1 and UltIMMa-2 was sourced from the European Union. Comparability between non–US-approved ustekinumab and US-approved ustekinumab has not been established.

STELARA is a registered trademark of Johnson & Johnson. See US Prescribing Information for further information.

STUDY DESIGN:

The randomized controlled trial data shown here are integrated results from UltIMMa-1 and -2. The open-label extension (OLE) data are a sub-analysis of LIMMitless and include only patients from UltIMMa-1 and -2 who completed the RCT and then enrolled in the OLE. LIMMitless is an OLE for which patients who completed either UltIMMa trial, IMMhance, or IMMvent were eligible to participate.4-7

VIEW STUDY DESIGN AND BASELINE CHARACTERISTICS

LOCF=Last observation carried forward; OLE=Open-label extension; RCT=Randomized controlled trial.

In the randomized controlled trial and open-label extension

PATIENTS WHO STARTED AND REMAINED ON SKYRIZI EXPERIENCED CONSISTENT PASI 100 RATES AT 2.5 YEARS3,4

KEY VARIABLES MEASURED EVERY 12 WEEKS THROUGH OLE5,8:

sPGA 0/1, sPGA 0, PASI 75, PASI 90, and PASI 100

Following completion of the RCT period, patients on blinded STELARA were switched to open-label SKYRIZI.4

LIMITATIONS:

In an open-label extension, there is potential for enrichment of the long-term data in the remaining patient populations since patients who are unable to tolerate or do not respond to the drug often drop out.

*ACTIVE COMPARATOR

The ustekinumab used as a biologic active control in UltIMMa-1 and UltIMMa-2 was sourced from the European Union. Comparability between non–US-approved ustekinumab and US-approved ustekinumab has not been established.

STELARA is a registered trademark of Johnson & Johnson. See US Prescribing Information for further information.

61% OF SKYRIZI PATIENTS ACHIEVED COMPLETE CLEARANCE (PASI 100) AT WEEK 52 AND 63% AT WEEK 1363,4

INTEGRATED RESULTS FROM ULTIMMA-1 & -2 PATIENTS (LOCF)

Chart depicts 61% of patients achieved complete clearance (PASI 100) at week 52 and 63% at week 136. Chart depicts 61% of patients achieved complete clearance (PASI 100) at week 52 and 63% at week 136. Chart depicts 61% of patients achieved complete clearance (PASI 100) at week 52 and 63% at week 136.

KEY VARIABLES MEASURED EVERY 12 WEEKS THROUGH OLE5,8:

sPGA 0/1, sPGA 0, PASI 75, PASI 90, and PASI 100

Following completion of the RCT period, patients on blinded STELARA were switched to open-label SKYRIZI.4

LIMITATIONS:

In an open-label extension, there is potential for enrichment of the long-term data in the remaining patient populations since patients who are unable to tolerate or do not respond to the drug often drop out.

*ACTIVE COMPARATOR

The ustekinumab used as a biologic active control in UltIMMa-1 and UltIMMa-2 was sourced from the European Union. Comparability between non–US-approved ustekinumab and US-approved ustekinumab has not been established.

STELARA is a registered trademark of Johnson & Johnson. See US Prescribing Information for further information.

STUDY DESIGN:

The randomized controlled trial data shown here are integrated results from UltIMMa-1 and -2. The open-label extension (OLE) data are a sub-analysis of LIMMitless and include only patients from UltIMMa-1 and -2 who completed the RCT and then enrolled in the OLE. LIMMitless is an OLE for which patients who completed either UltIMMa trial, IMMhance, or IMMvent were eligible to participate.4-7

VIEW STUDY DESIGN AND BASELINE CHARACTERISTICS

LOCF=Last observation carried forward; OLE=Open-label extension; RCT=Randomized controlled trial.

VIEW PASI 90 DATA