COVID-19 and Vaccine Update

Nothing Is Everything Header

Nothing less than the opportunity to reach for their treatment goals

For your patients,
that’s everything.

THE #1
PRESCRIBED
BIOLOGIC

for new and switching patients with plaque psoriasis2*

NOW

APPROVED FOR

adults with active PsA1

In Ps, most patients achieved co-primary endpoints of PASI 90 and sPGA 0/1 at Week 16, including response 4 weeks after 1st dose. Most patients who achieved PASI 90 at Week 16 maintained it at Week 52. PASI 100 was achieved by many patients at Week 16 and by a majority at Week 521,3,4

In PsA, a majority of patients achieved the primary endpoint of ACR20 at Week 24, experiencing improvement in joint symptoms including patient-reported pain data.1

Reliable quarterly dosing after 2 initiation doses at Weeks 0 and 4 (150 mg/dose) for Ps and PsA.1

PASI 90=≥90% improvement in Psoriasis Area and Severity Index; PASI 100=100% improvement in Psoriasis Area and Severity Index; sPGA 0/1=static Physician’s Global Assessment rating of clear or almost clear.

Skyrizi single-dose pen.

THE ONLY 4-DOSE-A-YEAR BIOLOGIC FOR PSORIASIS AND FOR PSORIATIC ARTHRITIS THAT OFFERS A SINGLE-DOSE PEN1

SKYRIZI® is the #1 prescribed biologic in new and switching plaque psoriasis patients.

 

*As of 10/2021. New patients defined as bio-naïve; switch patients defined as bio-experienced switching biologics. Source: Integrated Symphony Health (PatientSource) and IQVIA (NSP) through proprietary method on diagnosis classification.

99%

PREFERRED COMMERCIAL COVERAGE
FOR PATIENTS WITH Ps5

Preferred means the product is placed on the plan’s preferred formulary tier. Preferred products may also require a step edit depending on the product’s label. Non-preferred products require a higher out-of-pocket cost or step edit or are placed on a higher tier.

SKYRIZI SUPERIORITY DATA VS 3 AGENTS IN DIFFERENT BIOLOGIC CLASSES

Man in a blue swimsuit jumps into a lake

COSENTYX® (secukinumab)6‡

Woman in a blue dress raises her hands in celebration towards her friends

STELARA®
(ustekinumab)1,3§

Woman in blue top overlooking a lake

HUMIRA®
(adalimumab)7

Indication and Important Safety Information, including BOXED WARNING for Serious Infections and Malignancy.

SOURCING: In this study, 46 patients outside of the US received non–US-licensed secukinumab. Data regarding comparability between US and non-US secukinumab are not publicly available.8

§ACTIVE COMPARATOR: The ustekinumab used as a biologic active control in UltIMMa-1 and UltIMMa-2 was sourced from the European Union. Comparability between non–US-approved ustekinumab and US-approved ustekinumab has not been established.

At week 161,3: 75% of Skyrizi patients (n=220/294) achieved pasi 90 in the UltIMMa-2 study vs 2% of placebo patients (n=2/98);

84% of SKYRIZI patients achieved sPGA 0/1 vs 5% of placebo patients


UltlMMa-1 results at Week 16
PASI 90: SKYRIZI 75% (n=304), placebo 5% (n=102)
sPGA 0/1: SKYRIZI 88% (n=304), placebo 8% (n=102)

Co-primary endpoints for UltIMMa-1 and -2 were PASI 90 and sPGA 0/1 response vs placebo at Week 16.

P<0.0001 for comparisons of SKYRIZI vs placebo

STUDY DESIGN:

UltIMMa-1 (N=506) and UltIMMa-2 (N=491) were replicate Phase 3, randomized, double-blind, placebo- and active-controlled studies to evaluate the efficacy and safety of SKYRIZI (150 mg) vs placebo over 16 weeks and biologic active control (45 mg or 90 mg, based on screening weight) over 52 weeks in adult patients with moderate to severe plaque psoriasis.1,3


Woman in blue swimsuit Woman in blue swimsuit Woman in blue swimsuit

WATCH VIDEO:

SEE THE POSSIBILITIES WITH SKYRIZI

At week 521,3: 81% of Skyrizi patients (n=237/294) achieved pasi 90 in the UltIMMa-2 study; placebo did not continue beyond Week 16


UltlMMa-1 results at Week 52
PASI 90: SKYRIZI 82% (n=249/304), placebo n/a

Co-primary endpoints for UltIMMa-1 and -2 were PASI 90 and sPGA 0/1 response vs placebo at Week 16.

P<0.0001 for comparisons of SKYRIZI vs placebo

STUDY DESIGN:

UltIMMa-1 (N=506) and UltIMMa-2 (N=491) were replicate Phase 3, randomized, double-blind, placebo- and active-controlled studies to evaluate the efficacy and safety of SKYRIZI (150 mg) vs placebo over 16 weeks and biologic active control (45 mg or 90 mg, based on screening weight) over 52 weeks in adult patients with moderate to severe plaque psoriasis.1,3


4 doses
per year1


3-month dosing after 2 initiation
doses at Weeks 0 and 4 (150 mg/dose)1

NOW HAS PREFERRED|| COVERAGE
FOR 99% OF COMMERCIAL Ps PATIENTS5


 
Skyrizi® Complete Logo.

Eligible patients may be able to access their SKYRIZI at no charge until their insurance plan covers SKYRIZI

National commercial health plan formulary status under the pharmacy benefit updated as of January 2022.5

||Preferred means the product is placed on the plan’s preferred formulary tier. Preferred products may also require a step edit depending on the product’s label. Non-preferred products require a higher out-of-pocket cost or step edit or are placed on a higher tier. Based on formulary status under the pharmacy benefit.

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