
As of 9/2019. New patients defined as bio-naïve; switch patients
defined as bio-experienced switching biologics. Source: Integrated
Symphony Health (PatientSource) and IQVIA (NPA, NSP) through
proprietary method on diagnosis classification.
of NATIONAL commercial patients have
preferred coverage6*
*Formulary definitions: Preferred/Step 1 means the product is placed on the plan’s preferred formulary. Non-preferred products require a higher out-of-pocket cost or step edit, or are placed on a higher tier. Coverage means placed on formulary without a step edit through other biologics. For SKYRIZI, this could include coverage on a non-preferred tier, which may result in higher out-of-pocket cost. Based on formulary status under the pharmacy benefit.
National commercial health plan formulary status under the pharmacy benefit updated as of April 2020.6
At week 161,2: 75% of Skyrizi patients (n=294) achieved pasi 90 in the UltIMMa-2 study vs 2% placebo (n=98) patients
84% of SKYRIZI patients achieved sPGA 0/1 vs 5% placebo patients
UltlMMa-1 results at Week 16
PASI 90: SKYRIZI 75% (n=304), placebo 5% (n=102)
sPGA 0/1: SKYRIZI 88% (n=304), placebo 8% (n=102)
Co-primary endpoints for UltIMMa-1 and -2 were PASI 90 and sPGA 0/1 response vs placebo at Week 16.
P<0.0001 for comparisons of SKYRIZI vs placebo
STUDY DESIGN:
UltIMMa-1 (N=506) and UltIMMa-2 (N=491) were replicate phase 3, randomized, double-blind, placebo- and active-controlled studies to evaluate the efficacy and safety of SKYRIZI (150 mg) vs placebo over 16 weeks and biologic active control (45 mg or 90 mg, based on screening weight) over 52 weeks in adult patients with moderate to severe plaque psoriasis.1,2


At week 521,2: 81% of Skyrizi patients (n=294) achieved pasi 90 in the UltIMMa-2 study; placebo did not continue beyond Week 16
UltlMMa-1 results at Week 52
PASI 90: SKYRIZI 82% (n=304), placebo n/a
Co-primary endpoints for UltIMMa-1 and -2 were PASI 90 and sPGA 0/1 response vs placebo at Week 16.
P<0.0001 for comparisons of SKYRIZI vs placebo
STUDY DESIGN:
UltIMMa-1 (N=506) and UltIMMa-2 (N=491) were replicate phase 3, randomized, double-blind, placebo- and active-controlled studies to evaluate the efficacy and safety of SKYRIZI (150 mg) vs placebo over 16 weeks and biologic active control (45 mg or 90 mg, based on screening weight) over 52 weeks in adult patients with moderate to severe plaque psoriasis.1,2
4 doses per year1
3-month dosing after 2 initiation
doses at Weeks 0 and 4 (150 mg/dose)1


NOW HAS PREFERRED* COVERAGE
FOR >95% OF COMMERCIAL PATIENTS6

Eligible patients may be able to access their SKYRIZI at no charge until their insurance plan covers SKYRIZI
National commercial health plan formulary status under the pharmacy benefit updated as of April 2020.6
*Formulary definitions: Preferred/Step 1 means the product is placed on the plan’s preferred formulary. Non-preferred products require a higher out-of-pocket cost or step edit, or are placed on a higher tier.
Rapid.
Co-primary endpoints of PASI 90 and sPGA 0/1 at Week 16, including response 4 weeks after 1st dose1,3
*Preferred/Step 1 means the product is placed on the plan’s preferred formulary. Non-preferred products require a higher out-of-pocket cost or step edit, or are placed on a higher tier.
IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)1
Indication
SKYRIZI is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.
Important Safety Information
Infection
SKYRIZI may increase the risk of infection. Do not initiate treatment with SKYRIZI in patients with a clinically important active infection until it resolves or is adequately treated.
In patients with a chronic infection or a history of recurrent infection, consider the risks and benefits prior to prescribing SKYRIZI. Instruct patients to seek medical advice if signs or symptoms of clinically important infection occur. If a patient develops such an infection or is not responding to standard therapy, closely monitor and discontinue SKYRIZI until the infection resolves.
Pre-Treatment Evaluation for Tuberculosis (TB)
Prior to initiating treatment with SKYRIZI, evaluate for TB infection and consider treatment in patients with latent or active TB for whom an adequate course of treatment cannot be confirmed. Monitor patients for signs and symptoms of active TB during and after SKYRIZI treatment. Do not administer SKYRIZI to patients with active TB.
Immunizations
Prior to initiating SKYRIZI, consider completion of all age appropriate immunizations according to current immunization guidelines. Avoid use of live vaccines in patients treated with SKYRIZI.
Adverse Reactions
Most common (≥1 %) adverse reactions associated with SKYRIZI include upper respiratory infections, headache, fatigue, injection site reactions, and tinea infections.
Please see Full Prescribing Information.
US-SKZD-190350
REFERENCES
- SKYRIZI [package insert]. North Chicago, IL: AbbVie Inc.
- Gordon KB, Strober B, Lebwohl M, et al. Efficacy and safety of risankizumab in moderate-to-severe plaque psoriasis (UltIMMa-1 and UltIMMa-2): results from two double-blind, randomised, placebo-controlled and ustekinumab-controlled phase 3 trials. Lancet. 2018;392(10148):650-661.
- Lebwohl M, Bachelez H, Valdecantos WC, Wu T, Gordon K. Efficacy and safety of risankizumab in moderate-to-severe plaque psoriasis: an integrated analysis of UltIMMa-1 and UltIMMa-2. Poster presented at: American Academy of Dermatology Annual Meeting; March 1-5, 2019; Washington, DC.
- Warren RB, Blauvelt A, Poulin Y, et al. Risankizumab vs secukinumab in patients with moderate-to-severe plaque psoriasis: a phase 3 trial. Presented at the Virtual Annual Meeting of the American Academy of Dermatology; June 12-14, 2020.
- Data on file, AbbVie Inc. In-play patient share. 2020.
- Data on file, AbbVie Inc. MMIT-reported lives. 2020.