Our Products

Please see Important Safety Information, including BOXED WARNING on Serious Infections and Malignancy.

Please see Important Safety Information, including BOXED WARNING on Serious Infections, Malignancy, and Thrombosis.

Rheumatology

Please see Important Safety Information, including BOXED WARNING on Serious Inflections and Malignancy.

Please see Important Safety Information, including BOXED WARNING on Serious Inflections, Malignancy, and Thrombosis.

Moderate to Severe

Rheumatoid Arthritis

Please see Important Safety Information, including BOXED WARNING on Serious Inflections and Malignancy.

Please see Important Safety Information, including BOXED WARNING on Serious Inflections, Malignancy, and Thrombosis.

Active

Psoriatic Arthritis

Active

Ankylosing Spondylitis

Moderate to Severe

Juvenile Idiopathic Arthritis

Non-Infectious

Intermediate, Posterior and Panuveitis

Dermatology

Please see Important Safety Information, including BOXED WARNING on Serious Inflections and Malignancy.

Moderate to Severe

Chronic Plaque Psoriasis

Please see Important Safety Information, including BOXED WARNING on Serious Inflections and Malignancy.

Active

Psoriatic Arthritis

Moderate to Severe

Hidradenitis Suppurativa

Gastroenterology

Moderate to Severe

Crohn's Disease

Moderate to Severe

Pediatric Crohn's Disease

Moderate to Severe

Ulcerative Colitis

Ophthalmology

Non-Infectious

Intermediate, Posterior and Panuveitis

US-IMM-190099

The IL-23 inhibitor from AbbVie indicated for the treatment of moderate to severe plaque
psoriasis in adults who are candidates for systemic therapy or phototherapy¹

For Healthcare
Professionals

Resources for PATIENT ACCESS AND SUPPORT

PRACTICE FORMS AND RESOURCES PRACTICE FORMS AND RESOURCES

PATIENT FORMS AND RESOURCES PATIENT FORMS AND RESOURCES

Download forms to help patients get the support
they need to start and stay on track with SKYRIZI AS PRESCRIBED

This information is for informational purposes only and is not intended to provide reimbursement or legal advice. The information presented here does not guarantee payment or coverage.

Practice forms and resources

SKYRIZI COMPLETE ACCESS AND ONBOARDING TOOLS

Once you and your patient complete the Skyrizi Complete Enrollment and Prescription Form, simply fax it to Skyrizi Complete and inform your patient that they will be receiving a call from their Nurse Ambassador. If you complete the Pharmacy Prescription, also fax it to your patient’s chosen specialty pharmacy.

ACCESS GUIDE

SKYRIZI Complete Enrollment and Prescription Form

Access and reimbursement forms

Skyrizi Complete is here to help your patients get timely access to SKYRIZI. Along with requesting information from a Skyrizi Complete Access Specialist, you can download the forms you need to get started.

TEMPLATES

Appeals Letter Sample Template

Letter of Medical Necessity Sample Template

HIPAA AUTHORIZATION TEMPLATE

Formulary Exception Letter Sample Template

Tiered Exception Letter Sample Template

Here you can download helpful guidelines and tips for completing these templates.

Prior Authorization Instructions

Letter of Medical Necessity instructions

Formulary Exception Letter instructions

Tiered Exception Letter Instructions

Billing and Coding

Billing and Coding Guide

SPECIALTY PHARMACY

Specialty Pharmacy Resources

Download forms to help patients get the support
they need to start and stay on track with SKYRIZI AS PRESCRIBED

This information is for informational purposes only and is not intended to provide reimbursement or legal advice. The information presented here does not guarantee payment or coverage.

PATIENT FORMS AND RESOURCES

SKYRIZI COMPLETE ENROLLMENT

SKYRIZI Complete Enrollment and Prescription Form

ADDITIONAL RESOURCES

BENEFITS VERIFICATION CHART

PATIENT BROCHURE

INSURANCE COMPARISON

SKYRIZI COMPLETE BROCHURE

looking for more resources?Offer enrollment to patients and submit forms
electronically with CompletePro.com

By registering through CompletePro.com, you can choose the
capabilities that are most relevant to you and your patients' needs, such as:

Instant benefits verification:

Patient out-of-pocket costs
Any prior authorization requirements
Pharmacy options available to the patient
Patient eligibility for any drug discount from the pharmaceutical company

Online prescribing efficiencies:

Complete a Prior Authorization and send it directly to the insurer
Send a prescription directly to the patient's chosen pharmacy
Send Skyrizi Complete Savings Card to your patient's preferred specialty pharmacy (with or without a prescription)
Be notified via text, email, or website in advance of patient's prior authorization expiration
Easily access each patient's prescription fill status

Stay up to date on the latest SKYRIZI news and information

Get Skyrizi complete

Resources for your patients

Find out more

Only 4 doses per year

3-month dosing after 2 initiation doses at Weeks 0 and 4 (150 mg/dose)¹

View dosing schedule

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)¹

Indication

SKYRIZI is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.

Important Safety Information

Infection

SKYRIZI may increase the risk of infection. Do not initiate treatment with SKYRIZI in patients with a clinically important active infection until it resolves or is adequately treated.

In patients with a chronic infection or a history of recurrent infection, consider the risks and benefits prior to prescribing SKYRIZI. Instruct patients to seek medical advice if signs or symptoms of clinically important infection occur. If a patient develops such an infection or is not responding to standard therapy, closely monitor and discontinue SKYRIZI until the infection resolves.

Pre-Treatment Evaluation for Tuberculosis (TB)

Prior to initiating treatment with SKYRIZI, evaluate for TB infection and consider treatment in patients with latent or active TB for whom an adequate course of treatment cannot be confirmed. Monitor patients for signs and symptoms of active TB during and after SKYRIZI treatment. Do not administer SKYRIZI to patients with active TB.

Immunizations

Prior to initiating SKYRIZI, consider completion of all age appropriate immunizations according to current immunization guidelines. Avoid use of live vaccines in patients treated with SKYRIZI.

Adverse Reactions

Most common (≥1 %) adverse reactions associated with SKYRIZI include upper respiratory infections, headache, fatigue, injection site reactions, and tinea infections.

Please see Full Prescribing Information.

US-SKZD-190350

REFERENCE

SKYRIZI [package insert]. North Chicago, IL: AbbVie Inc.

SKYRIZI (risankizumab-rzaa) Injection Training Video

Hi, it’s good to be here with you. I’m Kate. And you are one of the many people who have been prescribed SKYRIZI. After starting on SKYRIZI, there were two directions you could go: continue with in-office injections or inject at home.

You had a discussion with your doctor, and have decided to inject at home.

I’m going to show you how to do that...step by step, and address any questions you may have.

Still, there are probably a million things you’d rather be doing right now than learning about injecting your medicine. I get it. But this video will be helpful. So, stay with it. Because, well, there’s more to making SKYRIZI a part of your life than just learning how to inject.

When you sign up for Skyrizi Complete, you get a dedicated Nurse Ambassador.

They will get to know you and help you start and stay on track with your treatment plan.

So, let’s get started.

Leave SKYRIZI at room temperature for 15 to 30 minutes before injecting.

If you’re a little nervous, I totally get it. It may help you relax if you watch or listen to something that is soothing.

First, wash your hands. Then get the things you need, and settle into a place where you feel relaxed.

Now I’ll take you through the process step by step.

Make sure you have everything you need laid out:

2 alcohol swabs that are included in the package,

2 cotton balls, you can also use gauze pads,

your sharps container, which ensures your syringes are disposed of safely,

and of course, your 2 SKYRIZI prefilled syringes.

For one full dose, two injections are required.

We’re going to break the injection process down into 4 simple steps.

Let’s call them the 4 Ps.

Pick the injection site.

Prepare the syringe.

Pinch the skin.

And Push the plunger in.

There’s an “R” too for “Repeat.” Remember, one dose is two injections.

So, you will need to repeat the same injection steps for the second injection.

Pick the injection site—your left or right thigh or your stomach.

When you are using your second syringe, pick an injection site at least one inch away from the first site. Do not inject into the same site.

If you choose your lower stomach area, make sure you inject at least 2 inches away from your belly button.

Wipe the injection site in a circular motion with the alcohol swab (before both injections). Don’t inject through clothes, or into skin that doesn’t look normal.

Start with one syringe for the first injection. Now prepare the syringe.

Holding the syringe with the needle pointing down, check the liquid in the syringe.

It is normal to see one or more bubbles in the window.

The liquid should look clear to slightly yellow and may contain tiny white or clear particles.

DO NOT use if the liquid is cloudy or contains flakes or large particles.

To remove the needle cover, hold the syringe in one hand.

With the other hand, gently pull the needle cover straight off and throw it away.

You may see a drop of liquid at the end of the needle. This is normal.

DO NOT touch the needle with your fingers or let the needle touch anything.

For this demonstration, I’ll be using a practice pad.

Hold the body of the prefilled syringe in one hand between the thumb and index finger.

Gently pinch the area of cleaned skin with your other hand and hold it firmly.

Insert the needle into the skin at about a 45 degree angle using a quick, short movement. Hold the angle steady.

Slowly push the plunger all the way in until all of the liquid is injected and the syringe is empty.

Pull the needle out of the skin while keeping the syringe at the same angle. Release the plunger and allow the syringe to move up until the entire needle is covered by the needle guard.

The syringe needle guard will not activate unless all the liquid has been injected.

Press a cotton ball or gauze pad over the injection site and hold for 10 seconds.

DO NOT rub the injection site. You may have slight bleeding. This is normal.

Now that the syringe is empty, drop it into the sharps container.

Repeat these injection steps for the second syringe immediately following your first injection. Do not inject into the same site.

Be sure to pick a new site at least one inch away from your first injection.

In a nutshell here’s what you did.

You picked the injection site, prepared the syringe, pinched the skin, and pushed the plunger in. Then you did it again, using the second syringe.

Okay, so now you know how to inject.

After your starter doses at week 0 and week 4, SKYRIZI is dosed quarterly. That’s just 4 times a year or one dose for each season.

It’s important you don’t forget.

So, make sure you place reminders for ordering your medication and note your injection day on your calendar. You can also do this through the Skyrizi Complete App.

The Skyrizi Complete Sharps Disposal and Mail-back Service ensures your syringes are disposed of safely and in a socially responsible way.

There’s a bit to remember.

But you’ll get the hang of it. And you can always refer to this video or call us.

You’ve got this.

US-SKZD-200213

Transcript

High Levels of Durable Skin Clearance

Uncovering Clearance

Watch Jeff Crowley, MD and Jennifer Soung, MD walk through the PASI 90 and PASI 100 data through 1 year of treatment with SKYRIZI.

Full Transcript

Please see Safety Considerations at the end of this video and review the full Prescribing Information available at SKYRIZIHCP.com.

Dr. Soung: Biologics have helped many patients with moderate to severe plaque psoriasis by offering additional treatment options for clearing skin.
Dr. Crowley: Today, Dr. Soung and I are going to share with you the key features of SKYRIZI and how it's helped patients like ours.

In 2 pivotal trials, UltIMMa-1 and UltIMMa-2, SKYRIZI was proven to deliver high levels of clearance in patients with moderate to severe plaque psoriasis, with 4 doses a year after 2 initial doses.

The co-primary endpoints in the trials were PASI 90 and sPGA O or 1 at Week 16 for SKYRIZI versus placebo. SKYRIZI met both co-primary endpoints in each trial. In addition to placebo, SKYRIZI was evaluated against a biologic active comparator, ustekinumab, which was sourced from the European Union. Comparability between non–US-approved ustekinumab and US-approved ustekinumab has not been established.

Dr. Soung: Let's take a look at SKYRIZl's 52-week data.

Here we see in this chart SKYRIZl's PASI 90 efficacy over 52 weeks from the pooled UltlMMa-1 and -2 trials. I want to bring your attention to the dosing schedule you see on the x-axis as indicated by an arrow.

After 2 doses of SKYRIZI, 75% of patients achieved PASI 90 at Week 16, compared to 4% for placebo. The dosing schedule is every 12 weeks for maintenance. At 1 year after 5 doses, the proportion of patients achieving PASI 90 increases to 81%.

In addition, SKYRIZI also maintained response over time. 88% of patients who saw PASI 90 results at Week 16 maintained PASI 90 at Week 52.

Many of my patients tell me that completely clear skin matters. Let's take a look at the PASI 100 responses from the pooled UltlMMa-1 and -2 trials.

43% of SKYRIZl-treated patients achieved PASI 100 at Week 16 after just 2 doses, compared to 1% with placebo. In 1 year, after just 5 doses, 58% of SKYRIZl-treated patients achieved PASI 100.

Dr. Crowley: Safety is another important consideration for patients and providers alike. SKYRIZI has a well-studied safety profile across 4 pivotal trials, with a total of 1,306 patients receiving SKYRIZI. Here we see the rates of adverse events through Week 16. In the trials, the SKYRIZI safety profile was similar to that of EU-sourced ustekinumab.

Rates of adverse events with SKYRIZI through 52 weeks were similar to the safety profile observed during the first 16 weeks.

With SKYRIZI, warnings and precautions include risk of infections, tuberculosis, and avoiding the use of live vaccines. There are no labeled warnings or precautions on malignancy, inflammatory bowel disease, or depression.

In summary, SKYRIZI offers patients with moderate to severe plaque psoriasis the opportunity for high levels of durable skin clearance with a well-studied safety profile, making it an excellent treatment option.

Dr. Soung: The fact that the majority of patients during the trials were completely clear at 1 year is exciting for our patients.

Indication

SKYRIZI is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.

Safety Considerations

SKYRIZI may increase the risk of infection. Instruct patients to report signs or symptoms of clinically important infection during treatment. Should such an infection occur, discontinue SKYRIZI until infection resolves. Evaluate patients for tuberculosis infection prior to initiating treatment with SKYRIZI. Avoid use of live vaccines in SKYRIZI patients.

Please see additional Important Safety Information at the bottom of this page. Please see full Prescribing Information by clicking the link at the top of this page.

US-SKZD-190187

Transcript

Expectation Setting and Mean PASI Data

Clear Conversations

Hear from Cynthia Trickett, PA-C, MPAS and Jason M. Cheyney, PA-C, MPAS as they cover how they discuss SKYRIZI skin clearance and safety data with patients.

Full Transcript

Please see Safety Considerations at the end of this video and review the full Prescribing Information available at SKYRIZIHCP.com.

Cynthia: When my patients start a biologic, having clear conversations on efficacy and safety are essential. Two common questions I get from patients are "How fast will this treatment work?" and "What are the risks?"

In 2 pivotal trials, UltlMMa-1 and UltlMMa-2, SKYRIZI demonstrated high levels of skin clearance in patients with moderate to severe plaque psoriasis.

The co-primary endpoints in the trials were PASI 90 and sPGA O or 1 at Week 16 for SKYRIZI versus placebo. In both trials, the co-primary endpoints were met.

SKYRIZI patients also saw rapid responses. with results seen as early as Week 4.

Jason: It can be difficult at times for patients to understand PASI 90 data. Another way to help explain clinical trial results to patients is mean PASI.

Mean PASI improvement is the average improvement in skin clearance from baseline—it's what the average patient experienced in the clinical trials, measured at set time periods.

When discussing efficacy with my patients starting SKYRIZI, I incorporate mean PASI, which was a pre-specified non-ranked endpoint in the clinical trials.

I let my patients know that in the clinical trials, the average skin clearance on SKYRIZI was 58% from baseline at 4 weeks after just 1 dose. 91% clearance at 16 weeks after 2 doses, and 95% at 1 year after the 5th dose. In comparison, the PASI 90 response at Week 4 was 6%.

Individual results may vary for patients. 88% of PAS/ 90 responders at Week 16 maintained their response at Week 52.

Here, you can see rapid skin clearance on an actual patient from the UltlMMa-2 trial. As early as Week 4, this patient saw a 63% improvement in their skin after just 1 dose of SKYRIZI. At Week 16, the patient had 88% clearer skin, and at 1 year, the patient had 94% clearer skin from baseline.

Cynthia: In addition, SKYRIZI is dosed 4 times a year after 2 initiation doses—with 2 injections per dose. Patients have the flexibility to receive injections in-office or to self-inject after proper training.

Communicating the risks and benefits of a biologic like SKYRIZI is important. SKYRIZI has a well-studied safety profile across 4 pivotal trials, with a total of 1306 patients receiving SKYRIZI. The adverse events through Week 16 included upper respiratory infections, headache, fatigue, injection site reactions, and tinea infections.

With all biologics, I discuss important safety considerations. With SKYRIZI, I let patients know that warnings and precautions include risk of infections, tuberculosis, and avoiding the use of live vaccines.

There are no labeled warnings or precautions around malignancy, IBD, or depression. Also, there is no routine monitoring after an initial TB test.

Jason: In summary, I can communicate to my patients that SKYRIZI is proven to deliver high levels of skin clearance, including results as early as 4 weeks.

Cynthia: In addition, SKYRIZl's dosing schedule and well-studied safety profile are important pieces of my clear conversations with patients.

Indication

SKYRIZI is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.

Safety Considerations

Please see additional Important Safety Information at the bottom of this page. Please see full Prescribing Information by clicking the link at the top of this page.

US-SKZD-190188

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)¹

Infection SKYRIZI® may increase the risk of infection. Do not initiate treatment with SKYRIZI in patients with a clinically important active infection until it resolves or is adequately treated. Prior to initiating treatment with SKYRIZI, evaluate for TB infection and consider treatment in patients with latent or active TB for whom an adequate course of treatment cannot be confirmed. Monitor patients for signs and symptoms of active TB during and after SKYRIZI treatment. Do not administer SKYRIZI to patients with active TB.

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)¹

Infection SKYRIZI® may increase the risk of infection. Do not initiate treatment with SKYRIZI in patients with a clinically important active infection until it resolves

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)¹

Infection SKYRIZI® may increase the risk of infection. Do not initiate treatment with SKYRIZI in patients with a clinically important active infection until it resolves

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)¹

Indication

SKYRIZI is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.

Important Safety Information

Infection

SKYRIZI may increase the risk of infection. Do not initiate treatment with SKYRIZI in patients with a clinically important active infection until it resolves or is adequately treated.

Pre-Treatment Evaluation for Tuberculosis (TB)

Immunizations

Prior to initiating SKYRIZI, consider completion of all age appropriate immunizations according to current immunization guidelines. Avoid use of live vaccines in patients treated with SKYRIZI.

Adverse Reactions

Most common (≥1 %) adverse reactions associated with SKYRIZI include upper respiratory infections, headache, fatigue, injection site reactions, and tinea infections.

Please see Full Prescribing Information.

US-SKZD-190350

Our Products

Rheumatology

Moderate to Severe

Rheumatoid Arthritis

Active

Psoriatic Arthritis

Active

Ankylosing Spondylitis

Moderate to Severe

Juvenile Idiopathic Arthritis

Non-Infectious

Intermediate, Posterior and Panuveitis

Dermatology

Moderate to Severe

Chronic Plaque Psoriasis

Active

Psoriatic Arthritis

Moderate to Severe

Hidradenitis Suppurativa

Gastroenterology

Moderate to Severe

Crohn's Disease

Moderate to Severe

Pediatric Crohn's Disease

Moderate to Severe

Ulcerative Colitis

Ophthalmology

Non-Infectious

Intermediate, Posterior and Panuveitis

Resources for PATIENT ACCESS AND SUPPORT

looking for more resources?Offer enrollment to patients and submit forms electronically with CompletePro.com

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)1

Indication

Important Safety Information

STUDY DESIGN—IMMvent9

SELECTED BASELINE CHARACTERISTICS9,14

STUDY DESIGN—IMMhance1,10,15

SELECTED BASELINE CHARACTERISTICS10,16

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STUDY DESIGN – UltIMMa-1 and UltIMMa-21,21,21,8

SELECTED BASELINE CHARACTERISTICS228

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)1

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)1

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)1

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)1

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)1

Indication

Important Safety Information

looking for more resources?Offer enrollment to patients and submit forms
electronically with CompletePro.com

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)¹

STUDY DESIGN—IMMvent⁹

SELECTED BASELINE CHARACTERISTICS^9,14

STUDY DESIGN—IMMhance^1,10,15

SELECTED BASELINE CHARACTERISTICS^10,16

STUDY DESIGN – UltIMMa-1 and UltIMMa-2^1,2^1,2^1,8

SELECTED BASELINE CHARACTERISTICS²²⁸

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)¹

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)¹

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)¹

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)¹

IMPORTANT SAFETY INFORMATION AND INDICATION FOR SKYRIZI® (risankizumab-rzaa)¹