ENDOSCOPIC CONTROL: VISIBLE MUCOSAL IMPROVEMENT

SKYRIZI Achieved its Co-Primary Endpoint of Endoscopic Response at Week 12 and Week 521,3

Endoscopic response rates for SKYRIZI (risankizumab) in clinical trials. Results from the ADVANCE double-blind RCT at week 12 reveal a 40% response with SKYRIZI 600 mg IV versus 12% with placebo (p<0.001). FORTIFY double-blind RCT at week 52 shows a 48% response with SKYRIZI 360 mg SC versus 22% with placebo (p<0.05). Open-label extension (OLE) at week 152 indicates a 78% response with SKYRIZI 180/360 mg SC (pooled)

Results at 52 weeks are among 382 patients who achieved clinical response after 12 weeks of treatment with SKYRIZI in induction trials.1

aContinuous placebo data not intended for direct comparison.

*OLE Limitations: In an OLE, there is a potential for enrichment of the long-term data in the remaining patient populations since patients who are unable to tolerate or do not respond to the drug often drop out.

AO Disclosure: In an as observed (AO) analysis, missing visit data was excluded from calculations for that visit, which may increase the percent of responders. All observed data was used regardless of premature discontinuation of study drug, or initiation of concomitant medication. The same patient may not have a response at each timepoint.